The Commanders vs Colts Week 4 Odds set the stage for an early kickoff in London. Both teams entered at 1-2. The game is being played at Tottenham Hotspur Stadium.
Current Odds
As of kickoff on October 4, 2026, the Indianapolis Colts were 4.5 to 5-point favorites.
The total hovered near 46.5 points.
Colts -4.5
Over/Under 46.5
Colts moneyline sat around -220 to -230.
Commanders moneyline sat around +185 to +190.
Lines can still shift in-game.
Records Against the Spread and Straight Up
Washington sits at 1-2 overall.
They earned their first win last week against Seattle.
Indianapolis also stands at 1-2.
The Colts picked up a narrow victory over Houston.
Early-season ATS data is limited for both sides, but Washington is 2-1 ATS. Colts are 1-2.
Last Week
Marcus Mariota started and delivered a solid performance. He threw three touchdowns in the 33-31 win over the Seahawks. The defense forced key turnovers.
Meanwhile, the Colts edged the Texans 19-17. C.J. Stroud threw for 167 yards and a touchdown, while Spencer Shrader made four successful field goals
Both clubs arrived in London looking for a second straight win.
Relevant Past Trends
London games often feature slower starts and travel fatigue. Washington plays without Jayden Daniels again.
The Colts also face a short-handed Commanders receiving corps, as Terry McLaurin was ruled out very late in the week.
Home-field advantage does not apply in a neutral international venue.
Over/Under Analysis
The total opened higher and settled near 46.5 – that’s almost always a good opportunity to look at the over. Washington has gone over in all 3 games so far.
Fantasy Section
Commanders projected values (pre-game)
| Player | Pos | Projected Points | Notes |
|---|---|---|---|
| Marcus Mariota | QB | 14.5 – 17.0 | Full-time starter with increased volume |
| Stefon Diggs | WR | 11.5 – 14.0 (PPR) | Larger target share without McLaurin |
| Jacory Croskey-Merritt | RB | 10.0 – 13.0 | Lead back with White inactive |
| Dyami Brown / Antonio Williams | WR | 8.0 – 11.0 (PPR) | Filling McLaurin’s role |
| Chig Okonkwo | TE | 7.0 – 9.5 (PPR) | Returning from injury with opportunity |
Colts projected values (pre-game)
| Player | Pos | Projected Points | Notes |
|---|---|---|---|
| Daniel Jones | QB | 15.5 – 18.0 | Operating the full offense |
| Jonathan Taylor | RB | 14.0 – 17.0 (PPR) | Clear lead back and primary scorer |
| Josh Downs | WR | 11.0 – 13.5 (PPR) | Primary target without Keenan Allen |
| Michael Pittman Jr. / other WRs | WR | 9.0 – 12.0 (PPR) | Increased opportunities in the passing game |
| Tight End group | TE | 7.5 – 10.0 (PPR) | Red-zone upside expected |
Team Injury Reports
Commanders
OUT: QB Jayden Daniels (elbow), WR Terry McLaurin (hamstring), RB Rachaad White (shoulder), G Sam Cosmi (concussion), S Nick Cross (illness).
Colts
OUT: WR Keenan Allen (groin).
Reports reflected the final inactive lists released Sunday morning.
Head-to-Head Records
The Colts vs. Commanders rivalry has seen 34 games, with the Indianapolis Colts winning 21 games and the Washington Commanders winning 13 games. THey have only played each other three times since 2014, with the Colts winning two of them. Washington won the last game 17-16 in 2022.
Summary
The Commanders vs Colts Week 4 Odds make Indy the favorites but can they pull it off? Both teams seek momentum after their first wins but expect Washington to at least cover the spread. Despite recent trends, take the under.
Kickoff is 9:30 a.m. ET on NFL Network.
Betting Glossary
Spread / ATS: The number of points the favorite must win by.
Moneyline: A bet on which team wins the game outright.
Over/Under: A bet on whether total points go over or under the set number.
SU: Straight up (win-loss record without the spread).
ATS: Against the spread.